downer >> ˈdaʊnə
Definition: [noun] a depressant or tranquillizing drug, especially a barbiturate.
Example: during that week I was heavily doped on downers
Definition: [noun] a dispiriting or depressing experience or factor.
Example: the thought of the danger his son was in put something of a downer on the situation
Definition: [noun] a cow or other animal that has fallen down and cannot get to its feet unaided.